But in Cantley’s mouse model of colorectal cancer, he found an even more direct relationship between sugar, in the form of high-fructose corn syrup, and cancer. His research has led him to the conclusion that today’s “high consumption of sugar” is “almost certainly responsible for the increased rates of a variety of cancers in the developed world.”Ĭantley reached this conclusion based on the evidence connecting refined sugar to elevated insulin, and elevated insulin to cancer.
But he has stopped eating sugar himself for a simple reason.
#The secrets of underground medicine dr warburg tv
Cantley, in other words, could hardly be more different from the diet doctors on TV or on the cover of magazines in the grocery store. He has received several of the highest honors in his field, including the 2015 Canada Gairdner International Award, often a prelude to a Nobel Prize. Cantley does not write popular books or articles. Lewis Cantley, the scientist who pioneered the study of how insulin activates the pathways linked to cancer, is among the researchers who have grown alarmed about sugar. Drinking sugar-in soda or fruit juice-is thought to be worst of all. But nothing appears to drive the first stages of the process quite like refined sugar. If fat is eaten together with these carbohydrates, the insulin spike will lead that fat to be stored rather than burned, and that dietary fat, too, will contribute to the “overload” problem. Any carbohydrate that is rapidly digested-beer or bread, pasta, and cereals made with refined flour-will also spike glucose and insulin levels. Sugar is not the entire story of insulin resistance. Summary and excerpt courtesy of Sam Apple and Liveright Publishers. Ravenous will be available on May 25, 2021, and is currently available for pre-order. A tale of scientific discovery, personal peril, and the race to end a disastrous disease, Ravenous would be the stuff of the most inventive fiction were it not, in fact, true. Rooting his revelations in extensive archival research as well as dozens of interviews with today’s leading cancer authorities, Apple demonstrates how Warburg’s midcentury work may well hold the secret to why cancer became so common in the modern world and how we can reverse the trend. Remarkably, Warburg’s theory has undergone a resurgence in our own time, as scientists have begun to investigate the dangers of sugar and the link between obesity and cancer, finding that the way we eat can influence how cancer cells take up nutrients and grow. Though Warburg’s metabolic approach to cancer was considered groundbreaking, his work was soon eclipsed in the early postwar era, after the discovery of the structure of DNA set off a search for the genetic origins of cancer.
Setting Warburg’s work against an absorbing history of cancer science, Apple follows him as he arrives at his central belief that cancer is a problem of metabolism. Ironically, they viewed Warburg as Germany’s best chance of survival.
Hitler and other Nazi leaders, Apple shows, were deeply troubled by skyrocketing cancer rates across the Western world, viewing cancer as an existential threat akin to Judaism or homosexuality. With the Nazis goose-stepping their way across Europe, systematically rounding up and murdering millions of Jews, Warburg awoke each morning in an elegant, antiques-filled home and rode horses with his partner, Jacob Heiss, before delving into his research at the Kaiser Wilhelm Society. While the vast majority of Jewish scientists fled Germany in the anxious years leading up to World War II, Warburg remained in Berlin, working under the watchful eye of the dictatorship. In Ravenous, Sam Apple reclaims Otto Warburg as a forgotten, morally compromised genius who pursued cancer single-mindedly even as Europe disintegrated around him. Yet Hitler and his top advisors dreaded cancer, and protected Warburg in the hope that he could cure it. As a Jewish homosexual living openly with his male partner, Warburg represented all that the Third Reich abhorred. He was also among the most despised figures in Nazi Germany. The Nobel laureate Otto Warburg―a cousin of the famous finance Warburgs―was widely regarded in his day as one of the most important biochemists of the twentieth century, a man whose research was integral to humanity’s understanding of cancer. The extraordinary story of the Nazi-era scientific genius who discovered how cancer cells eat―and what it means for how we should.